DDX20 (DEAD-box helicase 20)

2007-04-01  

Identity

HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
DP103,GEMIN3
FUSION GENES

Other Information

Locus ID:

NCBI: 11218
MIM: 606168
HGNC: 2743
Ensembl: ENSG00000064703

Variants:

dbSNP: 11218
ClinVar: 11218
TCGA: ENSG00000064703
COSMIC: DDX20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064703ENST00000369702Q9UHI6
ENSG00000064703ENST00000475700E9PJ60
ENSG00000064703ENST00000533164Q9UHI6

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Survival motor neuron (SMN) complexKEGGhsa_M00426
Survival motor neuron (SMN) complexKEGGM00426
Gene ExpressionREACTOMER-HSA-74160
Metabolism of non-coding RNAREACTOMER-HSA-194441
snRNP AssemblyREACTOMER-HSA-191859

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183814632008Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer.105
191389932008Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.95
163015322005Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins.94
207329062010Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma.50
250839912014DEAD-box helicase DP103 defines metastatic potential of human breast cancers.46
205853412011Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan.43
221746812011Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis.39
228989982013MicroRNA-140 acts as a liver tumor suppressor by controlling NF-κB activity by directly targeting DNA methyltransferase 1 (Dnmt1) expression.36
202118032010Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes.25
208197782010MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.21

Citation

Dessen P

DDX20 (DEAD-box helicase 20)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47213/ddx20-(dead-box-helicase-20)