PHC2 (polyhomeotic homolog 2)

2007-04-01  

Identity

HGNC
LOCATION
1p35.1
LOCUSID
ALIAS
EDR2,HPH2,PH2
FUSION GENES

Other Information

Locus ID:

NCBI: 1912
MIM: 602979
HGNC: 3183
Ensembl: ENSG00000134686

Variants:

dbSNP: 1912
ClinVar: 1912
TCGA: ENSG00000134686
COSMIC: PHC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134686ENST00000257118Q8IXK0
ENSG00000134686ENST00000373418Q8IXK0
ENSG00000134686ENST00000373422B3KPJ4
ENSG00000134686ENST00000431992A0A0A0MSI2

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
SUMOylation of RNA binding proteinsREACTOMER-HSA-4570464

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
278273732016BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization.12
204719602010SIAH-1 interacts with mammalian polyhomeotic homologues HPH2 and affects its stability via the ubiquitin-proteasome pathway.3

Citation

Dessen P

PHC2 (polyhomeotic homolog 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47229/phc2