DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12)

2007-04-01  

Identity

HGNC
DNAJB12
LOCATION
10q22.1
LOCUSID
54788
ALIAS
DJ10
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54788
MIM: 608376
HGNC: 14891
Ensembl: ENSG00000148719

Variants:

dbSNP: 54788
ClinVar: 54788
TCGA: ENSG00000148719
COSMIC: DNAJB12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148719ENST00000338820J3KPS0
ENSG00000148719ENST00000394903J3KPS0
ENSG00000148719ENST00000444643Q9NXW2
ENSG00000148719ENST00000461919V9GY70
ENSG00000148719ENST00000463786V9GYN7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379250332024DNAJB12 and DNJB14 are non-redundant Hsp40 redox chaperones involved in endoplasmic reticulum protein reflux.0
379250332024DNAJB12 and DNJB14 are non-redundant Hsp40 redox chaperones involved in endoplasmic reticulum protein reflux.0
279166612017Tetrameric Assembly of K(+) Channels Requires ER-Located Chaperone Proteins.36
285362682017Endoplasmic reticulum stress-induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis.21
279166612017Tetrameric Assembly of K(+) Channels Requires ER-Located Chaperone Proteins.36
285362682017Endoplasmic reticulum stress-induced degradation of DNAJB12 stimulates BOK accumulation and primes cancer cells for apoptosis.21
247329122014Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure.10
247329122014Expression of DNAJB12 or DNAJB14 causes coordinate invasion of the nucleus by membranes associated with a novel nuclear pore structure.10
211482932011The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508.82
211482932011The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508.82
211501292010A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR.40
211501292010A novel ER J-protein DNAJB12 accelerates ER-associated degradation of membrane proteins including CFTR.40

Citation

Dessen P

DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47243/haematological-explorer/favicon/js/lib/jquery-3.5.1.min.js