PFKL (phosphofructokinase, liver type)

2007-04-01  

Identity

HGNC
PFKL
LOCATION
21q22.3
LOCUSID
5211
ALIAS
ATP-PFK,PFK-B,PFK-L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5211
MIM: 171860
HGNC: 8876
Ensembl: ENSG00000141959

Variants:

dbSNP: 5211
ClinVar: 5211
TCGA: ENSG00000141959
COSMIC: PFKL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141959ENST00000349048P17858
ENSG00000141959ENST00000397961F8WEU2
ENSG00000141959ENST00000628044F8WEU2

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pentose phosphate pathwayKEGGko00030
Fructose and mannose metabolismKEGGko00051
Galactose metabolismKEGGko00052
Glycolysis / GluconeogenesisKEGGhsa00010
Pentose phosphate pathwayKEGGhsa00030
Fructose and mannose metabolismKEGGhsa00051
Galactose metabolismKEGGhsa00052
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Metabolic pathwaysKEGGhsa01100
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
HIF-1 signaling pathwayKEGGhsa04066
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GlycolysisREACTOMER-HSA-70171
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382873712024EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL.2
383884302024Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma.0
382873712024EGR1 suppresses HCC growth and aerobic glycolysis by transcriptionally downregulating PFKL.2
383884302024Ubiquitin-specific protease 14 targets PFKL-mediated glycolysis to promote the proliferation and migration of oral squamous cell carcinoma.0
355114932022miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization.2
355114932022miR-21-5p/Tiam1-mediated glycolysis reprogramming drives breast cancer progression via enhancing PFKL stabilization.2
343204072021Selective activation of PFKL suppresses the phagocytic oxidative burst.51
343484862021Relocation of phosphofructokinases within epithelial cells is a novel event preceding breast cancer recurrence that accurately predicts patient outcomes.3
343204072021Selective activation of PFKL suppresses the phagocytic oxidative burst.51
343484862021Relocation of phosphofructokinases within epithelial cells is a novel event preceding breast cancer recurrence that accurately predicts patient outcomes.3
320153332020A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma.44
331411532020Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.17
320153332020A20 targets PFKL and glycolysis to inhibit the progression of hepatocellular carcinoma.44
331411532020Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.17
315140722019(125)I suppressed the Warburg effect viaregulating miR-338/PFKL axis in hepatocellular carcinoma.19

Citation

Dessen P

PFKL (phosphofructokinase, liver type)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47253/cancer-prone-explorer/img/js/js/lib/zoomerang.js