PFKL (phosphofructokinase, liver type)

2007-04-01  

Identity

HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
ATP-PFK,PFK-B,PFK-L
FUSION GENES

Other Information

Locus ID:

NCBI: 5211
MIM: 171860
HGNC: 8876
Ensembl: ENSG00000141959

Variants:

dbSNP: 5211
ClinVar: 5211
TCGA: ENSG00000141959
COSMIC: PFKL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141959ENST00000349048P17858
ENSG00000141959ENST00000397961F8WEU2
ENSG00000141959ENST00000628044F8WEU2

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pentose phosphate pathwayKEGGko00030
Fructose and mannose metabolismKEGGko00051
Galactose metabolismKEGGko00052
Glycolysis / GluconeogenesisKEGGhsa00010
Pentose phosphate pathwayKEGGhsa00030
Fructose and mannose metabolismKEGGhsa00051
Galactose metabolismKEGGhsa00052
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Metabolic pathwaysKEGGhsa01100
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
HIF-1 signaling pathwayKEGGhsa04066
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GlycolysisREACTOMER-HSA-70171
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
229235832012Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.197
286461052017The glycolytic enzyme phosphofructokinase-1 assembles into filaments.17
189961022009Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.11
182549752008Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat.5
304099702018TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation.5
206026152010Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?2
315140722019125I suppressed the Warburg effect viaregulating miR-338/PFKL axis in hepatocellular carcinoma.1

Citation

Dessen P

PFKL (phosphofructokinase, liver type)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47253/pfkl