LDHB (lactate dehydrogenase B)

2007-04-01  

Identity

HGNC
LDHB
LOCATION
12p12.1
LOCUSID
3945
ALIAS
HEL-S-281,LDH-B,LDH-H,LDHBD,TRG-5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3945
MIM: 150100
HGNC: 6541
Ensembl: ENSG00000111716

Variants:

dbSNP: 3945
ClinVar: 3945
TCGA: ENSG00000111716
COSMIC: LDHB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111716ENST00000350669P07195
ENSG00000111716ENST00000350669Q5U077
ENSG00000111716ENST00000396075A8MW50
ENSG00000111716ENST00000396076P07195
ENSG00000111716ENST00000396076Q5U077
ENSG00000111716ENST00000450584C9J7H8
ENSG00000111716ENST00000539782F5H793

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pyruvate metabolismKEGGko00620
Propanoate metabolismKEGGko00640
Glycolysis / GluconeogenesisKEGGhsa00010
Pyruvate metabolismKEGGhsa00620
Propanoate metabolismKEGGhsa00640
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Pyruvate metabolismREACTOMER-HSA-70268

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
231392102012An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.54
211997942011Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis.53
228912702012Serum lactate dehydrogenase predicts for overall survival benefit in patients with metastatic renal cell carcinoma treated with inhibition of mammalian target of rapamycin.47
252477022014Peroxisomal lactate dehydrogenase is generated by translational readthrough in mammals.43
236979912013Lactate dehydrogenase B: a metabolic marker of response to neoadjuvant chemotherapy in breast cancer.34
232247362013Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas.32
255245552015Oxamate-mediated inhibition of lactate dehydrogenase induces protective autophagy in gastric cancer cells: involvement of the Akt-mTOR signaling pathway.30
232660492013Serum lactic dehydrogenase strongly predicts survival in metastatic nasopharyngeal carcinoma treated with palliative chemotherapy.23
213562072011Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects.22
224618862012The role of LDH serum levels in predicting global outcome in HCC patients undergoing TACE: implications for clinical management.20

Citation

Dessen P

LDHB (lactate dehydrogenase B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47310/ldhb