COPS6 (COP9 signalosome subunit 6)

2007-04-01  

Identity

HGNC
COPS6
LOCATION
7q22.1
LOCUSID
10980
ALIAS
CSN6,MOV34-34KD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10980
MIM: 614729
HGNC: 21749
Ensembl: ENSG00000168090

Variants:

dbSNP: 10980
ClinVar: 10980
TCGA: ENSG00000168090
COSMIC: COPS6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168090ENST00000303904Q7L5N1
ENSG00000168090ENST00000418625E7EM64
ENSG00000168090ENST00000419210C9JQK5
ENSG00000168090ENST00000426712H7C3T0

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
213175352011Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.47
262675352015ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development.20
231878082012CDK inhibitor p57 (Kip2) is negatively regulated by COP9 signalosome subunit 6.18
275466212017CSN6 controls the proliferation and metastasis of glioblastoma by CHIP-mediated degradation of EGFR.16
173374512007The subunit CSN6 of the COP9 signalosome is cleaved during apoptosis.10
180605012008The COP9 signalosome-mediated deneddylation is stimulated by caspases during apoptosis.9
277488792016Quercetin-induced apoptosis of HT-29 colon cancer cells via inhibition of the Akt-CSN6-Myc signaling axis.9
259455422015Regulating the stability and localization of CDK inhibitor p27(Kip1) via CSN6-COP1 axis.8
263180362015COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer.7

Citation

Dessen P

COPS6 (COP9 signalosome subunit 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47367/cops6