CCNT1 (cyclin T1)

2007-04-01  

Identity

HGNC
LOCATION
12q13.11
LOCUSID
ALIAS
CCNT,CYCT1,HIVE1

Other Information

Locus ID:

NCBI: 904
MIM: 143055
HGNC: 1599
Ensembl: ENSG00000129315

Variants:

dbSNP: 904
ClinVar: 904
TCGA: ENSG00000129315
COSMIC: CCNT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129315ENST00000261900O60563
ENSG00000129315ENST00000417344O60563
ENSG00000129315ENST00000618666O60563
ENSG00000129315ENST00000640148A0A1W2PQ16

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription ElongationREACTOMER-HSA-167169
Tat-mediated elongation of the HIV-1 transcriptREACTOMER-HSA-167246
Formation of HIV-1 elongation complex containing HIV-1 TatREACTOMER-HSA-167200
HIV elongation arrest and recoveryREACTOMER-HSA-167287
Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
Pausing and recovery of HIV elongationREACTOMER-HSA-167290
Tat-mediated HIV elongation arrest and recoveryREACTOMER-HSA-167243
Pausing and recovery of Tat-mediated HIV elongationREACTOMER-HSA-167238
Host Interactions of HIV factorsREACTOMER-HSA-162909
Interactions of Tat with host cellular proteinsREACTOMER-HSA-176034
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionREACTOMER-HSA-2173796
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
1171353320017SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes.276
176902452007Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription.163
178556332007A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification.160
180398612008Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression.143
185665852008The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.121
128324722003MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.119
121770052002Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter.105
146277022004Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA.87
222057492012Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.73
169806112006Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation.63

Citation

Dessen P

CCNT1 (cyclin T1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47404/ccnt1-(cyclin-t1)