GPR39 (G protein-coupled receptor 39)

2007-04-01  

Identity

HGNC
LOCATION
2q21.2
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 2863
MIM: 602886
HGNC: 4496
Ensembl: ENSG00000183840

Variants:

dbSNP: 2863
ClinVar: 2863
TCGA: ENSG00000183840
COSMIC: GPR39

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183840ENST00000329321O43194
ENSG00000183840ENST00000622084A0A087WTL7

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169598332007GPR39 signaling is stimulated by zinc ions but not by obestatin.76
153835392004Common structural basis for constitutive activity of the ghrelin receptor family.67
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
199201392010A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors.48
170549112006Obestatin does not activate orphan G protein-coupled receptor GPR39.39
205225462010Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair.31
178859202007Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum.26
249679692014The zinc sensing receptor, ZnR/GPR39, controls proliferation and differentiation of colonocytes and thereby tight junction formation in the colon.21
185888832008Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39.16
225451092012Zinc sensing receptor signaling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin.15

Citation

Dessen P

GPR39 (G protein-coupled receptor 39)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47434/gpr39