KDM4B (lysine demethylase 4B)

2007-04-01  

Identity

HGNC
KDM4B
LOCATION
19p13.3
LOCUSID
23030
ALIAS
JMJD2B,MRD65,TDRD14B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23030
MIM: 609765
HGNC: 29136
Ensembl: ENSG00000127663

Variants:

dbSNP: 23030
ClinVar: 23030
TCGA: ENSG00000127663
COSMIC: KDM4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127663ENST00000159111A0A0C4DFL8
ENSG00000127663ENST00000381759O94953
ENSG00000127663ENST00000536461F5GX28
ENSG00000127663ENST00000588337K7ES23
ENSG00000127663ENST00000588361K7EQ54
ENSG00000127663ENST00000611640F5GX28

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565

References

Pubmed IDYearTitleCitations
189845852008The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF.122
187130682008Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha.119
215025052011Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.97
227702412012Histone demethylases KDM4B and KDM6B promotes osteogenic differentiation of human MSCs.97
214452752011Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.76
214452752011Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development.76
206827972010The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
240773482013JMJD2B promotes epithelial-mesenchymal transition by cooperating with β-catenin and enhances gastric cancer metastasis.36
221336762011Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer.32

Citation

Dessen P

KDM4B (lysine demethylase 4B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47437/kdm4b