HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3)

2007-04-01  

Identity

HGNC
HERC3
LOCATION
4q22.1
LOCUSID
8916
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8916
MIM: 605200
HGNC: 4876
Ensembl: ENSG00000287542

Variants:

dbSNP: 8916
ClinVar: 8916
TCGA: ENSG00000287542
COSMIC: HERC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000287542ENST00000512194H0Y8G9

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
387222782024HERC3 facilitates ERAD of select membrane proteins by recognizing membrane-spanning domains.0
387222782024HERC3 facilitates ERAD of select membrane proteins by recognizing membrane-spanning domains.0
365983292023HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity.7
365983292023HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity.7
350641082022HERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer.13
356379662022HERC3 directly targets RPL23A for ubiquitination degradation and further regulates Colorectal Cancer proliferation and the cell cycle.11
350641082022HERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer.13
356379662022HERC3 directly targets RPL23A for ubiquitination degradation and further regulates Colorectal Cancer proliferation and the cell cycle.11
308626932019HERC3-Mediated SMAD7 Ubiquitination Degradation Promotes Autophagy-Induced EMT and Chemoresistance in Glioblastoma.57
308626932019HERC3-Mediated SMAD7 Ubiquitination Degradation Promotes Autophagy-Induced EMT and Chemoresistance in Glioblastoma.57
298808572018ΔNp63α down-regulates c-Myc modulator MM1 via E3 ligase HERC3 in the regulation of cell senescence.20
298808572018ΔNp63α down-regulates c-Myc modulator MM1 via E3 ligase HERC3 in the regulation of cell senescence.20
264764522015The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation.20
264764522015The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation.20
221242662011Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.16

Citation

Dessen P

HERC3 (HECT and RLD domain containing E3 ubiquitin protein ligase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47468/meetings/css/card-gene.css