RNF123 (ring finger protein 123)

2007-04-01  

Identity

HGNC
RNF123
LOCATION
3p21.31
LOCUSID
63891
ALIAS
FP1477,KPC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 63891
MIM: 614472
HGNC: 21148
Ensembl: ENSG00000164068

Variants:

dbSNP: 63891
ClinVar: 63891
TCGA: ENSG00000164068
COSMIC: RNF123

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164068ENST00000327697Q5XPI4
ENSG00000164068ENST00000432042C9J266
ENSG00000164068ENST00000433785C9JI97
ENSG00000164068ENST00000443204F8WB91
ENSG00000164068ENST00000444689H7C3U1
ENSG00000164068ENST00000454491C9JN91
ENSG00000164068ENST00000457726C9JS59
ENSG00000164068ENST00000629802F8WB91

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368808412023The Tumor Suppressor Functions of Ubiquitin Ligase KPC1: From Cell-Cycle Control to NF-κB Regulator.3
368808412023The Tumor Suppressor Functions of Ubiquitin Ligase KPC1: From Cell-Cycle Control to NF-κB Regulator.3
339269232021Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain.20
348730642021A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC.1
339269232021Genome-wide association study identifies RNF123 locus as associated with chronic widespread musculoskeletal pain.20
348730642021A short binding site in the KPC1 ubiquitin ligase mediates processing of NF-κB1 p105 to p50: A potential for a tumor-suppressive PROTAC.1
331687382020Excess of the NF-ĸB p50 subunit generated by the ubiquitin ligase KPC1 suppresses tumors via PD-L1- and chemokines-mediated mechanisms.11
331687382020Excess of the NF-ĸB p50 subunit generated by the ubiquitin ligase KPC1 suppresses tumors via PD-L1- and chemokines-mediated mechanisms.11
296765282018E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.20
296765282018E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.20
283895112017Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.21
286016552017Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas.6
283895112017Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.21
286016552017Regulation of p27 by ubiquitin ligases and its pathological significance in human lung carcinomas.6
273121092016RNF123 has an E3 ligase-independent function in RIG-I-like receptor-mediated antiviral signaling.11

Citation

Dessen P

RNF123 (ring finger protein 123)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47473/haematological-explorer/js/lib/zoomerang.js