POFUT1 (protein O-fucosyltransferase 1)

2007-04-01  

Identity

HGNC
POFUT1
LOCATION
20q11.21
LOCUSID
23509
ALIAS
DDD2,FUT12,O-FUT,O-Fuc-T,O-FucT-1,OFUCT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23509
MIM: 607491
HGNC: 14988
Ensembl: ENSG00000101346

Variants:

dbSNP: 23509
ClinVar: 23509
TCGA: ENSG00000101346
COSMIC: POFUT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101346ENST00000375730Q9H488
ENSG00000101346ENST00000375749Q9H488

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Other types of O-glycan biosynthesisKEGGko00514
Other types of O-glycan biosynthesisKEGGhsa00514
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Processing in the Endoplasmic ReticulumREACTOMER-HSA-1912399

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385003862024POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal cancer associated with MUC2 expression.0
389760172024Analysis of endogenous NOTCH1 from POFUT1 S162L patient fibroblasts reveals the importance of the O-fucose modification on EGF12 in human development.0
385003862024POFUT1 and PLAGL2 are characteristic markers of mucinous colorectal cancer associated with MUC2 expression.0
389760172024Analysis of endogenous NOTCH1 from POFUT1 S162L patient fibroblasts reveals the importance of the O-fucose modification on EGF12 in human development.0
366240912023Circular RNA circPOFUT1 enhances malignant phenotypes and autophagy-associated chemoresistance via sequestrating miR-488-3p to activate the PLAG1-ATG12 axis in gastric cancer.3
374325152023Preliminary study on the mechanism of POFUT1 in colorectal cancer.0
376411602023Overexpression of POFUT1 promotes malignant phenotype and mediates perineural invasion in head and neck squamous cell carcinoma.1
366240912023Circular RNA circPOFUT1 enhances malignant phenotypes and autophagy-associated chemoresistance via sequestrating miR-488-3p to activate the PLAG1-ATG12 axis in gastric cancer.3
374325152023Preliminary study on the mechanism of POFUT1 in colorectal cancer.0
376411602023Overexpression of POFUT1 promotes malignant phenotype and mediates perineural invasion in head and neck squamous cell carcinoma.1
342515842021POFUT1 acts as a tumor promoter in glioblastoma by enhancing the activation of Notch signaling.7
342515842021POFUT1 acts as a tumor promoter in glioblastoma by enhancing the activation of Notch signaling.7
314117362020Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression.24
314117362020Molecular characterization of colorectal adenomas reveals POFUT1 as a candidate driver of tumor progression.24
312011432019poFUT1 promotes endometrial decidualization by enhancing the O-fucosylation of Notch1.10

Citation

Dessen P

POFUT1 (protein O-fucosyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47518/cancer-prone-explorer/gene-explorer/css/favicon/favicon-32x32.png