TAOK2 (TAO kinase 2)

2007-06-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
MAP3K17,PSK,PSK1,PSK1-BETA,TAO1,TAO2
FUSION GENES

Other Information

Locus ID:

NCBI: 9344
MIM: 613199
HGNC: 16835
Ensembl: ENSG00000149930

Variants:

dbSNP: 9344
ClinVar: 9344
TCGA: ENSG00000149930
COSMIC: TAOK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149930ENST00000279394Q9UL54
ENSG00000149930ENST00000308893Q9UL54
ENSG00000149930ENST00000416441Q9UL54
ENSG00000149930ENST00000543033Q9UL54

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
226836812012Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.56
192425452009Association and mutation analyses of 16p11.2 autism candidate genes.35
168938902006Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways.24
126399632003The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability.20
171588782007Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing.13
126655132003TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors.12
235855622013Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease.12
288309822017Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells.5
283853312017Generalized verrucosis and abnormal T cell activation due to homozygous TAOK2 mutation.1

Citation

Dessen P

TAOK2 (TAO kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/47560/taok2-(tao-kinase-2)