RTN3 (reticulon 3)

2007-06-01  

Identity

HGNC
RTN3
LOCATION
11q13.1
LOCUSID
10313
ALIAS
ASYIP,HAP,NSPL2,NSPLII,RTN3-A1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10313
MIM: 604249
HGNC: 10469
Ensembl: ENSG00000133318

Variants:

dbSNP: 10313
ClinVar: 10313
TCGA: ENSG00000133318
COSMIC: RTN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133318ENST00000339997O95197
ENSG00000133318ENST00000341307O95197
ENSG00000133318ENST00000354497O95197
ENSG00000133318ENST00000356000O95197
ENSG00000133318ENST00000377819O95197
ENSG00000133318ENST00000536011B7Z4M1
ENSG00000133318ENST00000537981O95197
ENSG00000133318ENST00000537981A0A024R5C4
ENSG00000133318ENST00000540798O95197
ENSG00000133318ENST00000542238F5H617
ENSG00000133318ENST00000543552F5H891
ENSG00000133318ENST00000545432F5GWG7

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Alzheimer's diseaseKEGGko05010
Alzheimer's diseaseKEGGhsa05010
Neuronal SystemREACTOMER-HSA-112316
SALM protein interactions at the synapsesREACTOMER-HSA-8849932
Protein-protein interactions at synapsesREACTOMER-HSA-6794362

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383361462024RTN3 deficiency exacerbates cisplatin-induced acute kidney injury through the disruption of mitochondrial stability.0
383361462024RTN3 deficiency exacerbates cisplatin-induced acute kidney injury through the disruption of mitochondrial stability.0
373184532023RTN3 and RTN4: Architects of SARS-CoV-2 replication organelles.1
373184532023RTN3 and RTN4: Architects of SARS-CoV-2 replication organelles.1
355960612022Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells.5
355960612022Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells.5
334345262021Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites.31
334912572021LINC02288 promotes chondrocyte apoptosis and inflammation through miR-374a-3p targeting RTN3.10
339248902021The Implication of Reticulons (RTNs) in Neurodegenerative Diseases: From Molecular Mechanisms to Potential Diagnostic and Therapeutic Approaches.4
343132262021RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination.7
334345262021Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites.31
334912572021LINC02288 promotes chondrocyte apoptosis and inflammation through miR-374a-3p targeting RTN3.10
339248902021The Implication of Reticulons (RTNs) in Neurodegenerative Diseases: From Molecular Mechanisms to Potential Diagnostic and Therapeutic Approaches.4
343132262021RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination.7
329415102020Reticulon-3 modulates the incorporation of replication competent hepatitis C virus molecules for release inside infectious exosomes.5

Citation

Dessen P

RTN3 (reticulon 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/47562/deep-insight-explorer/css/template-nav.css