NODAL (nodal growth differentiation factor)

2007-07-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
HTX5
FUSION GENES

Other Information

Locus ID:

NCBI: 4838
MIM: 601265
HGNC: 7865
Ensembl: ENSG00000156574

Variants:

dbSNP: 4838
ClinVar: 4838
TCGA: ENSG00000156574
COSMIC: NODAL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156574ENST00000287139Q96S42
ENSG00000156574ENST00000414871H7C0E4

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
TGF-beta signaling pathwayKEGGko04350
TGF-beta signaling pathwayKEGGhsa04350
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Developmental BiologyREACTOMER-HSA-1266738
Signaling by NODALREACTOMER-HSA-1181150
Regulation of signaling by NODALREACTOMER-HSA-1433617

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
161796082005Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.291
192791332009Activin/Nodal signalling maintains pluripotency by controlling Nanog expression.144
84299081993Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation.115
155012272004Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway.109
180221512008Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm.102
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
217413762011Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs.71
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
154759562004Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway.67
153086652004Expression of nodal, lefty-a, and lefty-B in undifferentiated human embryonic stem cells requires activation of Smad2/3.62

Citation

Dessen P

NODAL (nodal growth differentiation factor)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47626/nodal