SERPINF2 (serpin family F member 2)

2007-07-01  

Identity

HGNC
SERPINF2
LOCATION
17p13.3
LOCUSID
5345
ALIAS
A2AP,AAP,ALPHA-2-PI,API,PLI,alpha2AP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5345
MIM: 613168
HGNC: 9075
Ensembl: ENSG00000167711

Variants:

dbSNP: 5345
ClinVar: 5345
TCGA: ENSG00000167711
COSMIC: SERPINF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167711ENST00000324015P08697
ENSG00000167711ENST00000382061P08697
ENSG00000167711ENST00000450523P08697
ENSG00000167711ENST00000453066C9JMH6
ENSG00000167711ENST00000453723C9JPV4

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Dissolution of Fibrin ClotREACTOMER-HSA-75205

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
348304192021Fibrinogen and Antifibrinolytic Proteins: Interactions and Future Therapeutics.5
348304192021Fibrinogen and Antifibrinolytic Proteins: Interactions and Future Therapeutics.5
316533472020Identification of glycated and acetylated lysine residues in human α2-antiplasmin.1
328159152020Interaction of glycated and acetylated human α2-antiplasmin with fibrin clots.3
329453902020Decrease in matrix metalloproteinase‑3 activity in systemic sclerosis fibroblasts causes α2‑antiplasmin and extracellular matrix deposition, and contributes to fibrosis development.8
316533472020Identification of glycated and acetylated lysine residues in human α2-antiplasmin.1
328159152020Interaction of glycated and acetylated human α2-antiplasmin with fibrin clots.3
329453902020Decrease in matrix metalloproteinase‑3 activity in systemic sclerosis fibroblasts causes α2‑antiplasmin and extracellular matrix deposition, and contributes to fibrosis development.8
300202412019Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia.9
311292632019A new ELISA method for the measurement of total α(2)-plasmin inhibitor level in human body fluids.4
312829892019Abnormal fibrinolysis recognized by thromboelastography in a case of severe bleeding with normal coagulation and platelet function, leads to detection of a novel SERPINF2 variant causing severe alpha-2-antiplasmin deficiency.1
300202412019Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia.9
311292632019A new ELISA method for the measurement of total α(2)-plasmin inhibitor level in human body fluids.4
312829892019Abnormal fibrinolysis recognized by thromboelastography in a case of severe bleeding with normal coagulation and platelet function, leads to detection of a novel SERPINF2 variant causing severe alpha-2-antiplasmin deficiency.1
293066022018Alpha-2-antiplasmin Arg407Lys polymorphism and cryptogenic ischemic cerebrovascular events: Association with neurological deficit.2

Citation

Dessen P

SERPINF2 (serpin family F member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47650/favicon/favicon-32x32.png