B4GALT2 (beta-1,4-galactosyltransferase 2)

2007-08-01 Affiliation

Identity

HGNC

B4GALT2

LOCATION

1p34.1

LOCUSID

8704

ALIAS

B4Gal-T2,B4Gal-T3,beta4Gal-T2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 8704
MIM: 604013
HGNC: 925
Ensembl: ENSG00000117411

Variants:

dbSNP: 8704
ClinVar: 8704
TCGA: ENSG00000117411
COSMIC: B4GALT2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000117411	ENST00000309519	O60909
ENSG00000117411	ENST00000356836	O60909
ENSG00000117411	ENST00000372324	O60909
ENSG00000117411	ENST00000434555	O60909

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Galactose metabolism	KEGG	ko00052
N-Glycan biosynthesis	KEGG	ko00510
Other types of O-glycan biosynthesis	KEGG	ko00514
Glycosaminoglycan biosynthesis - keratan sulfate	KEGG	ko00533
Glycosphingolipid biosynthesis - lacto and neolacto series	KEGG	ko00601
Galactose metabolism	KEGG	hsa00052
N-Glycan biosynthesis	KEGG	hsa00510
Other types of O-glycan biosynthesis	KEGG	hsa00514
Glycosaminoglycan biosynthesis - keratan sulfate	KEGG	hsa00533
Glycosphingolipid biosynthesis - lacto and neolacto series	KEGG	hsa00601
Metabolic pathways	KEGG	hsa01100
N-glycan biosynthesis, complex type	KEGG	hsa_M00075
Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer	KEGG	hsa_M00071
Glycosphingolipid biosynthesis, neolacto-series, LacCer => nLc4Cer	KEGG	M00071
N-glycan biosynthesis, complex type	KEGG	M00075
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Transport to the Golgi and subsequent modification	REACTOME	R-HSA-948021
N-glycan antennae elongation in the medial/trans-Golgi	REACTOME	R-HSA-975576
N-Glycan antennae elongation	REACTOME	R-HSA-975577
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glycosaminoglycan metabolism	REACTOME	R-HSA-1630316
Keratan sulfate/keratin metabolism	REACTOME	R-HSA-1638074
Keratan sulfate biosynthesis	REACTOME	R-HSA-2022854
Mannose type O-glycan biosynthesis	KEGG	ko00515
Mannose type O-glycan biosynthesis	KEGG	hsa00515

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD
PA166124406	platelet reactivity	Disease	VariantAnnotation	associated	PD
PA443796	Coronary Artery Disease	Disease	VariantAnnotation	associated	PD
PA448497	aspirin	Chemical	VariantAnnotation	associated	PD
PA449053	clopidogrel	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
27004849	2016	Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.	11
19524017	2009	Site directed processing: role of amino acid sequences and glycosylation of acceptor glycopeptides in the assembly of extended mucin type O-glycan core 2.	9
15504978	2004	Tumor necrosis factor-alpha in diabetic plasma increases the activity of core 2 GlcNAc-T and adherence of human leukocytes to retinal endothelial cells: significance of core 2 GlcNAc-T in diabetic retinopathy.	8
15939404	2005	beta4GalT-II is a key regulator of glycosylation of the proteins involved in neuronal development.	6
18211920	2008	Identification of beta1,4GalT II as a target gene of p53-mediated HeLa cell apoptosis.	6
17470362	2007	beta4GalT-II increases cisplatin-induced apoptosis in HeLa cells depending on its Golgi localization.	1
30020015	2018	Beta-1,4-galactosyltransferase 2 c.909C>T gene variant is predictive of on-clopidogrel platelet reactivity.	1

Citation

Dessen P

B4GALT2 (beta-1,4-galactosyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47673/b4galt2-(beta-1-4-galactosyltransferase-2)