GGCT (gamma-glutamylcyclotransferase)

2007-08-01  

Identity

HGNC
LOCATION
7p14.3
LOCUSID
ALIAS
C7orf24,CRF21,GCTG,GGC
FUSION GENES

Other Information

Locus ID:

NCBI: 79017
MIM: 137170
HGNC: 21705
Ensembl: ENSG00000006625

Variants:

dbSNP: 79017
ClinVar: 79017
TCGA: ENSG00000006625
COSMIC: GGCT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006625ENST00000005374O75223
ENSG00000006625ENST00000275428O75223
ENSG00000006625ENST00000275428A0A090N7V5
ENSG00000006625ENST00000409144O75223
ENSG00000006625ENST00000409390O75223
ENSG00000006625ENST00000409436B8ZZK2
ENSG00000006625ENST00000426081H7BZK5
ENSG00000006625ENST00000440082A0A0B4J1Y4
ENSG00000006625ENST00000447901A0A0B4J1Y4

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Glutathione metabolismKEGGhsa00480
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Glutathione synthesis and recyclingREACTOMER-HSA-174403

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
352137202022MiR-205-5p/GGCT Attenuates Growth and Metastasis of Papillary Thyroid Cancer by Regulating CD44.9
362332932022Interaction of MRPL9 and GGCT Promotes Cell Proliferation and Migration by Activating the MAPK/ERK Pathway in Papillary Thyroid Cancer.5
352137202022MiR-205-5p/GGCT Attenuates Growth and Metastasis of Papillary Thyroid Cancer by Regulating CD44.9
362332932022Interaction of MRPL9 and GGCT Promotes Cell Proliferation and Migration by Activating the MAPK/ERK Pathway in Papillary Thyroid Cancer.5
341210382021miR-877 inhibits the proliferation, migration, and invasion of osteosarcoma cells by targeting gamma-glutamylcyclotransferase.2
347942212021[The expression of GGCT in the bladder urothelial cell carcinoma and its clinical significance].0
341210382021miR-877 inhibits the proliferation, migration, and invasion of osteosarcoma cells by targeting gamma-glutamylcyclotransferase.2
347942212021[The expression of GGCT in the bladder urothelial cell carcinoma and its clinical significance].0
317576772020γ-Glutamyl cyclotransferase contributes to endometrial carcinoma malignant progression and upregulation of PD-L1 expression during activation of epithelial-mesenchymal transition.2
317576772020γ-Glutamyl cyclotransferase contributes to endometrial carcinoma malignant progression and upregulation of PD-L1 expression during activation of epithelial-mesenchymal transition.2
312170772019Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression.5
313455732019Depletion of gamma-glutamylcyclotransferase inhibits cancer cell growth by activating the AMPK-FOXO3a-p21 axis.9
312170772019Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression.5
313455732019Depletion of gamma-glutamylcyclotransferase inhibits cancer cell growth by activating the AMPK-FOXO3a-p21 axis.9
293078342018Prohibitin-2 is a novel regulator of p21(WAF1/CIP1) induced by depletion of γ-glutamylcyclotransferase.3

Citation

Dessen P

GGCT (gamma-glutamylcyclotransferase)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47695/css/favicon/favicon-32x32.png