ZDHHC9 (zinc finger DHHC-type palmitoyltransferase 9)

2007-08-01  

Identity

HGNC
ZDHHC9
LOCATION
Xq26.1
LOCUSID
51114
ALIAS
CGI89,CXorf11,DHHC9,MMSA1,MRXSZ,ZDHHC10,ZNF379,ZNF380
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51114
MIM: 300646
HGNC: 18475
Ensembl: ENSG00000188706

Variants:

dbSNP: 51114
ClinVar: 51114
TCGA: ENSG00000188706
COSMIC: ZDHHC9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188706ENST00000357166Q9Y397
ENSG00000188706ENST00000371064Q9Y397
ENSG00000188706ENST00000406492Q5JYE8
ENSG00000188706ENST00000433917H0Y6K6

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
213888132011DHHC palmitoyl transferases: substrate interactions and (patho)physiology.129
160002962005DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.114
175198972007Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups.23
242485992014Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases.14
248111722014Mutations in the X-linked intellectual disability gene, zDHHC9, alter autopalmitoylation activity by distinct mechanisms.12
264934792016Palmitoylacyltransferase Zdhhc9 inactivation mitigates leukemogenic potential of oncogenic Nras.11
281682882017Global and Local Connectivity Differences Converge With Gene Expression in a Neurodevelopmental Disorder of Known Genetic Origin.5
286875272017The first patient with sporadic X-linked intellectual disability with de novo ZDHHC9 mutation identified by targeted next-generation sequencing.5
277471532016Structural brain abnormalities in a single gene disorder associated with epilepsy, language impairment and intellectual disability.4
263585592016Tentative clinical diagnosis of Lujan-Fryns syndrome--A conglomeration of different genetic entities?3

Citation

Dessen P

ZDHHC9 (zinc finger DHHC-type palmitoyltransferase 9)

Atlas Genet Cytogenet Oncol Haematol. 2007-08-01

Online version: http://atlasgeneticsoncology.org/gene/47719/zdhhc9