WASF2 (WASP family member 2)

2007-09-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
IMD2,SCAR2,WASF4,WAVE2,dJ393P12.2
FUSION GENES

Other Information

Locus ID:

NCBI: 10163
MIM: 605875
HGNC: 12733
Ensembl: ENSG00000158195

Variants:

dbSNP: 10163
ClinVar: 10163
TCGA: ENSG00000158195
COSMIC: WASF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158195ENST00000536657Q9Y6W5
ENSG00000158195ENST00000618852Q9Y6W5

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Adherens junctionKEGGko04520
Regulation of actin cytoskeletonKEGGko04810
Adherens junctionKEGGhsa04520
Regulation of actin cytoskeletonKEGGhsa04810
ShigellosisKEGGhsa05131
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
150481232004Abi1 is essential for the formation and activation of a WAVE2 signalling complex.142
199172582009Activation of the WAVE complex by coincident signals controls actin assembly.115
164014212006The WAVE2 complex regulates actin cytoskeletal reorganization and CRAC-mediated calcium entry during T cell activation.95
150707262004Purification and architecture of the ubiquitous Wave complex.90
156571362005Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation.80
151078622004PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia.76
230517392012A WAVE2-Arp2/3 actin nucleator apparatus supports junctional tension at the epithelial zonula adherens.57
167022312006Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac.55
188097282008The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1.51
175916932007WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse.47

Citation

Dessen P

WASF2 (WASP family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49745/wasf2