SRCIN1 (SRC kinase signaling inhibitor 1)

2007-09-01  

Identity

HGNC
SRCIN1
LOCATION
17q12
LOCUSID
80725
ALIAS
P140,SNIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80725
MIM: 610786
HGNC: 29506
Ensembl: ENSG00000277363

Variants:

dbSNP: 80725
ClinVar: 80725
TCGA: ENSG00000277363
COSMIC: SRCIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000277363ENST00000612431A0A087WU33
ENSG00000277363ENST00000613927A0A087WTE6
ENSG00000277363ENST00000617146Q9C0H9
ENSG00000277363ENST00000621492A0A087X165
ENSG00000277363ENST00000622190A0A087WVV7
ENSG00000277363ENST00000622519A0A590UJ70

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
371697372023p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response.3
371697372023p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response.3
330792272021The p140Cap adaptor protein as a molecular hub to block cancer aggressiveness.4
330792272021The p140Cap adaptor protein as a molecular hub to block cancer aggressiveness.4
312855462020The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma.11
323237982020lncRNA TPTEP1 competitively sponges miR‑328‑5p to inhibit the proliferation of non‑small cell lung cancer cells.16
329249852020FOXD3-AS1 suppresses the progression of non-small cell lung cancer by regulating miR-150/SRCIN1axis.8
329640352020SRCIN1 Regulated by circCCDC66/miR-211 Is Upregulated and Promotes Cell Proliferation in Non-Small-Cell Lung Cancer.8
312855462020The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma.11
323237982020lncRNA TPTEP1 competitively sponges miR‑328‑5p to inhibit the proliferation of non‑small cell lung cancer cells.16
329249852020FOXD3-AS1 suppresses the progression of non-small cell lung cancer by regulating miR-150/SRCIN1axis.8
329640352020SRCIN1 Regulated by circCCDC66/miR-211 Is Upregulated and Promotes Cell Proliferation in Non-Small-Cell Lung Cancer.8
303028132019miR-17-5p promotes proliferation and epithelial-mesenchymal transition in human osteosarcoma cells by targeting SRC kinase signaling inhibitor 1.13
303158502019MiR-150 promotes angiogensis and proliferation of endothelial progenitor cells in deep venous thrombosis by targeting SRCIN1.19
308902782019MicroRNA-374a promotes pancreatic cancer cell proliferation and epithelial to mesenchymal transition by targeting SRCIN1.11

Citation

Dessen P

SRCIN1 (SRC kinase signaling inhibitor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49749/css/haematological-explorer/js/lib/js/lib/bootstrap.min.js