SRCIN1 (SRC kinase signaling inhibitor 1)

2007-09-01  

Identity

HGNC
LOCATION
17q12
LOCUSID
ALIAS
P140,SNIP
FUSION GENES

Other Information

Locus ID:

NCBI: 80725
MIM: 610786
HGNC: 29506
Ensembl: ENSG00000277363

Variants:

dbSNP: 80725
ClinVar: 80725
TCGA: ENSG00000277363
COSMIC: SRCIN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000277363ENST00000612431A0A087WU33
ENSG00000277363ENST00000613927A0A087WTE6
ENSG00000277363ENST00000617146Q9C0H9
ENSG00000277363ENST00000621492A0A087X165
ENSG00000277363ENST00000622190A0A087WVV7
ENSG00000277363ENST00000622519A0A590UJ70

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
244567952014miR-150 promotes the proliferation and migration of lung cancer cells by targeting SRC kinase signalling inhibitor 1.49
255544192015miR-374a promotes cell proliferation, migration and invasion by targeting SRCIN1 in gastric cancer.37
175257342007p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity.29
204538862010p140Cap dual regulation of E-cadherin/EGFR cross-talk and Ras signalling in tumour cell scatter and proliferation.23
262777872016miR-211 promotes non-small cell lung cancer proliferation by targeting SRCIN1.15
279131852017MiR-346 promotes the biological function of breast cancer cells by targeting SRCIN1 and reduces chemosensitivity to docetaxel.13
257716852015Endophilin A1 regulates dendritic spine morphogenesis and stability through interaction with p140Cap.12
303158502019MiR-150 promotes angiogensis and proliferation of endothelial progenitor cells in deep venous thrombosis by targeting SRCIN1.8
285506792018Downregulation of SRC Kinase Signaling Inhibitor 1 (SRCIN1) Expression by MicroRNA-32 Promotes Proliferation and Epithelial-Mesenchymal Transition in Human Liver Cancer Cells.7
184752972008SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue.6

Citation

Dessen P

SRCIN1 (SRC kinase signaling inhibitor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49749/srcin1-(src-kinase-signaling-inhibitor-1)