OAZ1 (ornithine decarboxylase antizyme 1)

2007-10-01  

Identity

HGNC
OAZ1
LOCATION
19p13.3
LOCUSID
4946
ALIAS
AZ1,AZI,OAZ
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4946
MIM: 601579
HGNC: 8095
Ensembl: ENSG00000104904

Variants:

dbSNP: 4946
ClinVar: 4946
TCGA: ENSG00000104904
COSMIC: OAZ1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104904ENST00000582888J3QQY4
ENSG00000104904ENST00000588673K7ERW1
ENSG00000104904ENST00000590943K7EPM6
ENSG00000104904ENST00000602676P54368

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202
Regulation of ornithine decarboxylase (ODC)REACTOMER-HSA-350562

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373259742023EPLIN-β is a novel substrate of ornithine decarboxylase antizyme 1 and mediates cellular migration.1
373259742023EPLIN-β is a novel substrate of ornithine decarboxylase antizyme 1 and mediates cellular migration.1
321818102020Translation efficiency affects the sequence-independent +1 ribosomal frameshifting by polyamines.1
321818102020Translation efficiency affects the sequence-independent +1 ribosomal frameshifting by polyamines.1
263059482015Structural basis of antizyme-mediated regulation of polyamine homeostasis.40
263059482015Structural basis of antizyme-mediated regulation of polyamine homeostasis.40
241927812014Assay of OAZ1 mRNA levels in chronic myeloid leukemia combined with application of leukemia PCR array identified relevant gene changes affected by antizyme.4
249300352014Antizyme (AZ) regulates intestinal cell growth independent of polyamines.7
253185492014Effects of ornithine decarboxylase antizyme 1 on the proliferation and differentiation of human oral cancer cells.6
241927812014Assay of OAZ1 mRNA levels in chronic myeloid leukemia combined with application of leukemia PCR array identified relevant gene changes affected by antizyme.4
249300352014Antizyme (AZ) regulates intestinal cell growth independent of polyamines.7
253185492014Effects of ornithine decarboxylase antizyme 1 on the proliferation and differentiation of human oral cancer cells.6
232601692013Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.17
232601692013Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.17
220082212012Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide.24

Citation

Dessen P

OAZ1 (ornithine decarboxylase antizyme 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-10-01

Online version: http://atlasgeneticsoncology.org/gene/49771/css/case-report-explorer/js/lib/zoomerang.js