TRIM45 (tripartite motif containing 45)

2007-12-01  

Identity

HGNC
LOCATION
1p13.1
LOCUSID
ALIAS
RNF99

Other Information

Locus ID:

NCBI: 80263
MIM: 609318
HGNC: 19018
Ensembl: ENSG00000134253

Variants:

dbSNP: 80263
ClinVar: 80263
TCGA: ENSG00000134253
COSMIC: TRIM45

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134253ENST00000256649Q9H8W5
ENSG00000134253ENST00000369461Q5T2K3
ENSG00000134253ENST00000369464Q9H8W5
ENSG00000134253ENST00000485032S4R407
ENSG00000134253ENST00000497970H0YCA7

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
226340062012TRIM45 negatively regulates NF-κB-mediated transcription and suppresses cell proliferation.12
153516932004TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1.11
246819542015The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway.11
285421452017TRIM45 functions as a tumor suppressor in the brain via its E3 ligase activity by stabilizing p53 through K63-linked ubiquitination.8

Citation

Dessen P

TRIM45 (tripartite motif containing 45)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49910/trim45