MAP3K15 (mitogen-activated protein kinase kinase kinase 15)

2007-12-01  

Identity

HGNC
MAP3K15
LOCATION
Xp22.12
LOCUSID
389840
ALIAS
ASK3,bA723P2.3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 389840
MIM: 300820
HGNC: 31689
Ensembl: ENSG00000180815

Variants:

dbSNP: 389840
ClinVar: 389840
TCGA: ENSG00000180815
COSMIC: MAP3K15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180815ENST00000338883Q6ZN16
ENSG00000180815ENST00000359173A0A140T8W5

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
363836752022Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes.10
363836752022Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes.10
336493092021Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose).33
336493092021Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose).33
321567832020Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases.9
321567832020Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases.9
295394112018A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress.15
295394112018A PP6-ASK3 Module Coordinates the Bidirectional Cell Volume Regulation under Osmotic Stress.15
203625542010ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells.17
203625542010ASK3, a novel member of the apoptosis signal-regulating kinase family, is essential for stress-induced cell death in HeLa cells.17

Citation

Dessen P

MAP3K15 (mitogen-activated protein kinase kinase kinase 15)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49916/teaching-explorer/favicon/favicon-32x32.png