NDRG4 (NDRG family member 4)

2007-12-01  

Identity

HGNC
NDRG4
LOCATION
16q21
LOCUSID
65009
ALIAS
BDM1,SMAP-8,SMAP8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 65009
MIM: 614463
HGNC: 14466
Ensembl: ENSG00000103034

Variants:

dbSNP: 65009
ClinVar: 65009
TCGA: ENSG00000103034
COSMIC: NDRG4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103034ENST00000258187Q9ULP0
ENSG00000103034ENST00000258187A0A024R6V8
ENSG00000103034ENST00000356752Q9ULP0
ENSG00000103034ENST00000394279Q9ULP0
ENSG00000103034ENST00000394279A0A024R6V8
ENSG00000103034ENST00000394282Q9ULP0
ENSG00000103034ENST00000561724H3BR92
ENSG00000103034ENST00000561738H3BNE7
ENSG00000103034ENST00000561779H3BVF3
ENSG00000103034ENST00000562731H3BST8
ENSG00000103034ENST00000562764H3BPT6
ENSG00000103034ENST00000562930H3BPY2
ENSG00000103034ENST00000562999H3BQJ4
ENSG00000103034ENST00000563799Q9ULP0
ENSG00000103034ENST00000563978H3BQ01
ENSG00000103034ENST00000564126H3BM40
ENSG00000103034ENST00000564207H3BNQ1
ENSG00000103034ENST00000564486H3BQ86
ENSG00000103034ENST00000564867H3BUH4
ENSG00000103034ENST00000565088H3BU08
ENSG00000103034ENST00000565304H3BN53
ENSG00000103034ENST00000565430H3BPH8
ENSG00000103034ENST00000565434H3BRT9
ENSG00000103034ENST00000566041H3BNB4
ENSG00000103034ENST00000566061H3BS80
ENSG00000103034ENST00000566192Q9ULP0
ENSG00000103034ENST00000566192A0A0S2Z5L7
ENSG00000103034ENST00000566618H3BSC3
ENSG00000103034ENST00000566656H3BUK1
ENSG00000103034ENST00000567063H3BM83
ENSG00000103034ENST00000567454H3BNX9
ENSG00000103034ENST00000567667H3BMR6
ENSG00000103034ENST00000568424H3BVB0
ENSG00000103034ENST00000568464H3BMG5
ENSG00000103034ENST00000568640Q9ULP0
ENSG00000103034ENST00000568999H3BN97
ENSG00000103034ENST00000569026H3BPQ3
ENSG00000103034ENST00000569404H3BNK4
ENSG00000103034ENST00000569408H3BM44
ENSG00000103034ENST00000569539H3BU25
ENSG00000103034ENST00000569923B7Z9X4
ENSG00000103034ENST00000570248Q9ULP0
ENSG00000103034ENST00000570248A0A0S2Z5R7

Expression (GTEx)

0
100
200
300
400
500
600
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
193054082009Common variants at ten loci influence QT interval duration in the QTGEN Study.190
119368452002Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family.72
195357832009N-Myc downstream-regulated gene 4 (NDRG4): a candidate tumor suppressor gene and potential biomarker for colorectal cancer.62
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
195924882009NDRG4 is required for cell cycle progression and survival in glioblastoma cells.21
224898212012NDRG4 is downregulated in glioblastoma and inhibits cell proliferation.13
228690422012NDRG4, the N-Myc downstream regulated gene, is important for cell survival, tumor invasion and angiogenesis in meningiomas.12
280429542017NDRG4 hypermethylation is a potential biomarker for diagnosis and prognosis of gastric cancer in Chinese population.12
164083042006Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation.10
237257562013NDRG3 and NDRG4, two novel tumor-related genes.10

Citation

Dessen P

NDRG4 (NDRG family member 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49948/ndrg4-(ndrg-family-member-4)