YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta)

2008-01-01  

Identity

HGNC
LOCATION
2p25.1
LOCUSID
ALIAS
14-3-3,1C5,HS1
FUSION GENES

Other Information

Locus ID:

NCBI: 10971
MIM: 609009
HGNC: 12854
Ensembl: ENSG00000134308

Variants:

dbSNP: 10971
ClinVar: 10971
TCGA: ENSG00000134308
COSMIC: YWHAQ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134308ENST00000238081P27348
ENSG00000134308ENST00000381844P27348
ENSG00000134308ENST00000446619E9PG15

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Pathogenic Escherichia coli infectionKEGGko05130
Cell cycleKEGGhsa04110
Pathogenic Escherichia coli infectionKEGGhsa05130
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BAD and translocation to mitochondriaREACTOMER-HSA-111447

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378045922023Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein.0
38001539202314-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2.1
378045922023Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein.0
38001539202314-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2.1
330452802021STAT3 couples with 14-3-3σ to regulate BCR signaling, B-cell differentiation, and IgE production.3
335564062021Structural Insights into the Interaction Between CRTCs and 14-3-3.5
337232532021Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms.37
342177852021A feedback circuit comprising EHD1 and 14-3-3ζ sustains β-catenin/c-Myc-mediated aerobic glycolysis and proliferation in non-small cell lung cancer.8
344873242021Genetic Prion Disease: Insight from the Features and Experience of China National Surveillance for Creutzfeldt-Jakob Disease.10
345041012021TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.11
330452802021STAT3 couples with 14-3-3σ to regulate BCR signaling, B-cell differentiation, and IgE production.3
335564062021Structural Insights into the Interaction Between CRTCs and 14-3-3.5
337232532021Hierarchized phosphotarget binding by the seven human 14-3-3 isoforms.37
342177852021A feedback circuit comprising EHD1 and 14-3-3ζ sustains β-catenin/c-Myc-mediated aerobic glycolysis and proliferation in non-small cell lung cancer.8
344873242021Genetic Prion Disease: Insight from the Features and Experience of China National Surveillance for Creutzfeldt-Jakob Disease.10

Citation

Dessen P

YWHAQ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49987/favicon/js/lib/css/lib/dataTables.bootstrap.min.css