YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)

2008-01-01  

Identity

HGNC
YWHAZ
LOCATION
8q22.3
LOCUSID
7534
ALIAS
14-3-3-zeta,HEL-S-3,HEL-S-93,HEL4,KCIP-1,POPCHAS,YWHAD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7534
MIM: 601288
HGNC: 12855
Ensembl: ENSG00000164924

Variants:

dbSNP: 7534
ClinVar: 7534
TCGA: ENSG00000164924
COSMIC: YWHAZ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164924ENST00000353245P63104
ENSG00000164924ENST00000353245D0PNI1
ENSG00000164924ENST00000395948B0AZS6
ENSG00000164924ENST00000395951P63104
ENSG00000164924ENST00000395951D0PNI1
ENSG00000164924ENST00000395953P63104
ENSG00000164924ENST00000395953D0PNI1
ENSG00000164924ENST00000395956P63104
ENSG00000164924ENST00000395956D0PNI1
ENSG00000164924ENST00000395957P63104
ENSG00000164924ENST00000395957D0PNI1
ENSG00000164924ENST00000395958P63104
ENSG00000164924ENST00000395958D0PNI1
ENSG00000164924ENST00000418997E7EVZ2
ENSG00000164924ENST00000419477P63104
ENSG00000164924ENST00000419477D0PNI1
ENSG00000164924ENST00000437293E9PD24
ENSG00000164924ENST00000457309P63104
ENSG00000164924ENST00000457309D0PNI1
ENSG00000164924ENST00000521309B7Z2E6
ENSG00000164924ENST00000521328E7ESK7
ENSG00000164924ENST00000521607E7EX29
ENSG00000164924ENST00000522542P63104
ENSG00000164924ENST00000522819B7Z2E6
ENSG00000164924ENST00000523131E5RIR4
ENSG00000164924ENST00000523848H0YB80
ENSG00000164924ENST00000523938E5RGE1

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Pathogenic Escherichia coli infectionKEGGko05130
Cell cycleKEGGhsa04110
Pathogenic Escherichia coli infectionKEGGhsa05130
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Rap1 signallingREACTOMER-HSA-392517
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
GP1b-IX-V activation signallingREACTOMER-HSA-430116
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
KSRP (KHSRP) binds and destabilizes mRNAREACTOMER-HSA-450604
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BAD and translocation to mitochondriaREACTOMER-HSA-111447

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381948032024CSF 14-3-3 zeta(ζ) isoform is associated with tau pathology and cognitive decline in Alzheimer's disease.0
38325743202414-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway.0
383414722024TMEM65 promotes gastric tumorigenesis by targeting YWHAZ to activate PI3K-Akt-mTOR pathway and is a therapeutic target.1
386743342024Structural Features and Physiological Associations of Human 14-3-3ζ Pseudogenes.0
381948032024CSF 14-3-3 zeta(ζ) isoform is associated with tau pathology and cognitive decline in Alzheimer's disease.0
38325743202414-3-3 interaction with phosphodiesterase 8A sustains PKA signaling and downregulates the MAPK pathway.0
383414722024TMEM65 promotes gastric tumorigenesis by targeting YWHAZ to activate PI3K-Akt-mTOR pathway and is a therapeutic target.1
386743342024Structural Features and Physiological Associations of Human 14-3-3ζ Pseudogenes.0
360013422023YWHAZ variation causes intellectual disability and global developmental delay with brain malformation.5
369776052023Discovery of 14-3-3 zeta as a potential biomarker for cardiac hypertrophy.0
372249612023Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex.2
374520332023High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis.1
360013422023YWHAZ variation causes intellectual disability and global developmental delay with brain malformation.5
369776052023Discovery of 14-3-3 zeta as a potential biomarker for cardiac hypertrophy.0
372249612023Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex.2

Citation

Dessen P

YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49997/case-report-explorer/haematological-explorer/css/card-gene.css