YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)

2008-01-01  

Identity

HGNC
LOCATION
8q22.3
LOCUSID
ALIAS
14-3-3-zeta,HEL-S-3,HEL-S-93,HEL4,KCIP-1,POPCHAS,YWHAD
FUSION GENES

Other Information

Locus ID:

NCBI: 7534
MIM: 601288
HGNC: 12855
Ensembl: ENSG00000164924

Variants:

dbSNP: 7534
ClinVar: 7534
TCGA: ENSG00000164924
COSMIC: YWHAZ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164924ENST00000353245P63104
ENSG00000164924ENST00000353245D0PNI1
ENSG00000164924ENST00000395948B0AZS6
ENSG00000164924ENST00000395951P63104
ENSG00000164924ENST00000395951D0PNI1
ENSG00000164924ENST00000395953P63104
ENSG00000164924ENST00000395953D0PNI1
ENSG00000164924ENST00000395956P63104
ENSG00000164924ENST00000395956D0PNI1
ENSG00000164924ENST00000395957P63104
ENSG00000164924ENST00000395957D0PNI1
ENSG00000164924ENST00000395958P63104
ENSG00000164924ENST00000395958D0PNI1
ENSG00000164924ENST00000418997E7EVZ2
ENSG00000164924ENST00000419477P63104
ENSG00000164924ENST00000419477D0PNI1
ENSG00000164924ENST00000437293E9PD24
ENSG00000164924ENST00000457309P63104
ENSG00000164924ENST00000457309D0PNI1
ENSG00000164924ENST00000521309B7Z2E6
ENSG00000164924ENST00000521328E7ESK7
ENSG00000164924ENST00000521607E7EX29
ENSG00000164924ENST00000522542P63104
ENSG00000164924ENST00000522819B7Z2E6
ENSG00000164924ENST00000523131E5RIR4
ENSG00000164924ENST00000523848H0YB80
ENSG00000164924ENST00000523938E5RGE1

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Pathogenic Escherichia coli infectionKEGGko05130
Cell cycleKEGGhsa04110
Pathogenic Escherichia coli infectionKEGGhsa05130
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Rap1 signallingREACTOMER-HSA-392517
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
GP1b-IX-V activation signallingREACTOMER-HSA-430116
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Deactivation of the beta-catenin transactivating complexREACTOMER-HSA-3769402
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
KSRP (KHSRP) binds and destabilizes mRNAREACTOMER-HSA-450604
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BAD and translocation to mitochondriaREACTOMER-HSA-111447

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
104070191999alpha-Synuclein shares physical and functional homology with 14-3-3 proteins.114
150376012004YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta.110
19732720200914-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition.90
233160052013αB-crystallin complexes with 14-3-3ζ to induce epithelial-mesenchymal transition and resistance to sorafenib in hepatocellular carcinoma.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
25670079201514-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2.58
185739122008Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity.57
181625322008Down-regulation of 14-3-3zeta suppresses anchorage-independent growth of lung cancer cells through anoikis activation.55
23622247201314-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins.47
204710302010Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia.42

Citation

Dessen P

YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/49997/ywhaz-(tyrosine-3-monooxygenase-tryptophan-5-monooxygenase-activation-protein-zeta)