LSR (lipolysis stimulated lipoprotein receptor)

2007-02-01  

Identity

HGNC
LSR
LOCATION
19q13.12
LOCUSID
51599
ALIAS
ILDR3,LISCH7
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51599
MIM: 616582
HGNC: 29572
Ensembl: ENSG00000105699

Variants:

dbSNP: 51599
ClinVar: 51599
TCGA: ENSG00000105699
COSMIC: LSR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105699ENST00000347609Q86X29
ENSG00000105699ENST00000354900Q86X29
ENSG00000105699ENST00000360798Q86X29
ENSG00000105699ENST00000361790Q86X29
ENSG00000105699ENST00000427250Q86X29
ENSG00000105699ENST00000599658M0QZL9
ENSG00000105699ENST00000601623M0R1W9
ENSG00000105699ENST00000602003M0R0W1
ENSG00000105699ENST00000602122Q86X29
ENSG00000105699ENST00000605618S4R3V8
ENSG00000105699ENST00000621372Q86X29

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
LDL-mediated lipid transportREACTOMER-HSA-171052
VLDL interactionsREACTOMER-HSA-8855121

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
212451992011LSR defines cell corners for tricellular tight junction formation in epithelial cells.64
222528692012Identification of the cellular receptor of Clostridium spiroforme toxin.24
236319182013Clostridium difficile binary toxin CDT induces clustering of the lipolysis-stimulated lipoprotein receptor into lipid rafts.17
258828472015Interaction of the Clostridium difficile Binary Toxin CDT and Its Host Cell Receptor, Lipolysis-stimulated Lipoprotein Receptor (LSR).11
179751472007Prognostic value of LISCH7 mRNA in plasma and tumor of colon cancer patients.10
280716802017Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer.9
270360402016The roles of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor in malignancy of human endometrial cancer cells.7
273910682017Loss of LSR affects epithelial barrier integrity and tumor xenograft growth of CaCo-2 cells.2
284932782017The bicellular tensile force sorts the localization of LSRs in bicellular and tricellular junctions.1
291783242018Effect of LSR polymorphism on blood lipid levels and age-specific epistatic interaction with the APOE common polymorphism.0

Citation

Dessen P

LSR (lipolysis stimulated lipoprotein receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50010/lsr