GTF2E1 (general transcription factor IIE subunit 1)

2007-02-01  

Identity

HGNC
GTF2E1
LOCATION
3q13.33
LOCUSID
2960
ALIAS
FE,TF2E1,TFIIE-A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2960
MIM: 189962
HGNC: 4650
Ensembl: ENSG00000153767

Variants:

dbSNP: 2960
ClinVar: 2960
TCGA: ENSG00000153767
COSMIC: GTF2E1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153767ENST00000283875P29083
ENSG00000153767ENST00000469772C9IYL4
ENSG00000153767ENST00000484715C9J329
ENSG00000153767ENST00000492959E9PER7

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Basal transcription factorsKEGGko03022
Basal transcription factorsKEGGhsa03022
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV Transcription InitiationREACTOMER-HSA-167161
RNA Polymerase II HIV Promoter EscapeREACTOMER-HSA-167162
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningREACTOMER-HSA-73779
RNA Polymerase II Transcription Initiation And Promoter ClearanceREACTOMER-HSA-76042
RNA Polymerase II Transcription InitiationREACTOMER-HSA-75953
RNA Polymerase II Promoter EscapeREACTOMER-HSA-73776
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
345536942021MicroRNA 452 regulates GTF2E1 expression in colorectal cancer cells.0
345818122021Nucleolar TFIIE plays a role in ribosomal biogenesis and performance.5
345536942021MicroRNA 452 regulates GTF2E1 expression in colorectal cancer cells.0
345818122021Nucleolar TFIIE plays a role in ribosomal biogenesis and performance.5
315290522019The hRPC62 subunit of human RNA polymerase III displays helicase activity.3
315290522019The hRPC62 subunit of human RNA polymerase III displays helicase activity.3
276027232016Dynamics of the Extended String-Like Interaction of TFIIE with the p62 Subunit of TFIIH.3
276394362016Crystal Structure of Human General Transcription Factor TFIIE at Atomic Resolution.10
276027232016Dynamics of the Extended String-Like Interaction of TFIIE with the p62 Subunit of TFIIH.3
276394362016Crystal Structure of Human General Transcription Factor TFIIE at Atomic Resolution.10
254926092015Association of the winged helix motif of the TFIIEα subunit of TFIIE with either the TFIIEβ subunit or TFIIB distinguishes its functions in transcription.2
254926092015Association of the winged helix motif of the TFIIEα subunit of TFIIE with either the TFIIEβ subunit or TFIIB distinguishes its functions in transcription.2
189508452009Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.5
189508452009Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.5
181605372008p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH.27

Citation

Dessen P

GTF2E1 (general transcription factor IIE subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50013/case-report-explorer/gene-explorer/js/js/lib/popper.js