MIR34A (microRNA 34a)

2007-02-01  

Identity

HGNC
MIR34A
LOCATION
1p36.22
LOCUSID
407040
ALIAS
MIRN34A,miRNA34A,mir-34,mir-34a
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 407040
MIM: 611172
HGNC: 31635
Ensembl: ENSG00000284357
miRBase:

Variants:

dbSNP: 407040
ClinVar: 407040
TCGA: ENSG00000284357
COSMIC: MIR34A

RNA/Proteins

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

References

Pubmed IDYearTitleCitations
187558972008miR-34a repression of SIRT1 regulates apoptosis.467
175541992007Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest.368
246424712014IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis.201
221343542011miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions.199
184063532008Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest.181
190066482009miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells.171
220241622011A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition.168
229753732012TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.155
196967872010p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC.141
236423682013A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells.141

Citation

Dessen P

MIR34A (microRNA 34a)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/50015/mir34a