ORM2 (orosomucoid 2)

2008-03-01  

Identity

HGNC
ORM2
LOCATION
9q32
LOCUSID
5005
ALIAS
AGP-B,AGP-B,AGP2

Other Information

Locus ID:

NCBI: 5005
MIM: 138610
HGNC: 8499
Ensembl: ENSG00000228278

Variants:

dbSNP: 5005
ClinVar: 5005
TCGA: ENSG00000228278
COSMIC: ORM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000228278ENST00000431067P19652

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445425Prostatic NeoplasmsDiseaseClinicalAnnotationassociatedPK24619498
PA449383docetaxelChemicalClinicalAnnotationassociatedPK24619498
PA451906warfarinChemicalVariantAnnotationnot associated19794411

References

Pubmed IDYearTitleCitations
170480072007Association of warfarin dose with genes involved in its action and metabolism.100
195841532009Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia.37
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
199580902009Genetic determinants of warfarin dosing in the Han-Chinese population.25
158633552005Glycosylation of site-specific glycans of alpha1-acid glycoprotein and alterations in acute and chronic inflammation.14
223637572012The potential role of ORM2 in the development of colorectal cancer.12
259658302015Orosomucoid 2 inhibits tumor metastasis and is upregulated by CCAAT/enhancer binding protein β in hepatocellular carcinomas.11
281936962017Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation.11
190185212009Investigation of genetic variants of alpha-1 acid glycoprotein by ultra-performance liquid chromatography-mass spectrometry.8
179876282007Comparison of alpha-1-acid glycoprotein isoforms from healthy and cancer patients by capillary IEF.4

Citation

Dessen P

ORM2 (orosomucoid 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50042/orm2