TET3 (tet methylcytosine dioxygenase 3)

2008-03-01  

Identity

HGNC
TET3
LOCATION
2p13.1
LOCUSID
200424
ALIAS
BEFAHRS,hCG_40738
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 200424
MIM: 613555
HGNC: 28313
Ensembl: ENSG00000187605

Variants:

dbSNP: 200424
ClinVar: 200424
TCGA: ENSG00000187605
COSMIC: TET3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187605ENST00000409262O43151

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
TET1,2,3 and TDG demethylate DNAREACTOMER-HSA-5221030

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194203522009Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.240
194203522009Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.240
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
243944112014Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).55
267034702016Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.53
238203842013Ten-eleven translocation (Tet) and thymine DNA glycosylase (TDG), components of the demethylation pathway, are direct targets of miRNA-29a.34
255683112015Phosphorylation of TET proteins is regulated via O-GlcNAcylation by the O-linked N-acetylglucosamine transferase (OGT).33
277295282016Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.31
262942122015Hypoxia Drives Breast Tumor Malignancy through a TET-TNFα-p38-MAPK Signaling Axis.30
243046612014TET3-OGT interaction increases the stability and the presence of OGT in chromatin.28

Citation

Dessen P

TET3 (tet methylcytosine dioxygenase 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50084/tet3