RRN3 (RRN3 homolog, RNA polymerase I transcription factor)

2008-04-01  

Identity

HGNC
RRN3
LOCATION
16p13.11
LOCUSID
54700
ALIAS
A-270G1.2,TIFIA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54700
MIM: 605121
HGNC: 30346
Ensembl: ENSG00000085721

Variants:

dbSNP: 54700
ClinVar: 54700
TCGA: ENSG00000085721
COSMIC: RRN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000085721ENST00000198767Q9NYV6
ENSG00000085721ENST00000327307Q9NYV6
ENSG00000085721ENST00000429751F5H148
ENSG00000085721ENST00000563559H3BMT1
ENSG00000085721ENST00000564131Q9NYV6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Transcription InitiationREACTOMER-HSA-73762
RNA Polymerase I Promoter EscapeREACTOMER-HSA-73772

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
150040092004mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability.161
126202282003ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth.85
123937492002Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter.35
219407642011Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth.33
185594192008Phosphorylation by casein kinase 2 facilitates rRNA gene transcription by promoting dissociation of TIF-IA from elongating RNA polymerase I.30
242979012013Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA.20
233931352013DNA binding by the ribosomal DNA transcription factor rrn3 is essential for ribosomal DNA transcription.14
180476492007Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene.13
298737802018Identification of a novel TIF-IA-NF-κB nucleolar stress response pathway.5
307937662019Ebp1 p48 promotes oncogenic activities in human colon cancer cells through regulation of TIF-90-mediated ribosomal RNA synthesis.1

Citation

Dessen P

RRN3 (RRN3 homolog, RNA polymerase I transcription factor)

Atlas Genet Cytogenet Oncol Haematol. 2008-04-01

Online version: http://atlasgeneticsoncology.org/gene/50094/rrn3