BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit)

2008-05-01  

Identity

HGNC
LOCATION
14q32.33
LOCUSID
ALIAS
BRF,BRF-1,CFDS,GTF3B,HEL-S-76p,TAF3B2,TAF3C,TAFIII90,TF3B90,TFIIIB90,hBRF
FUSION GENES

Other Information

Locus ID:

NCBI: 2972
MIM: 604902
HGNC: 11551
Ensembl: ENSG00000185024

Variants:

dbSNP: 2972
ClinVar: 2972
TCGA: ENSG00000185024
COSMIC: BRF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185024ENST00000327359Q92994
ENSG00000185024ENST00000379932F6VUY7
ENSG00000185024ENST00000379937Q92994
ENSG00000185024ENST00000392557Q92994
ENSG00000185024ENST00000392557A0A024R6P8
ENSG00000185024ENST00000440513Q92994
ENSG00000185024ENST00000446501Q92994
ENSG00000185024ENST00000546417H0YIV6
ENSG00000185024ENST00000547530Q92994
ENSG00000185024ENST00000548421Q92994
ENSG00000185024ENST00000548421V9HVY2
ENSG00000185024ENST00000549655F8VS45
ENSG00000185024ENST00000550208F8VWY1
ENSG00000185024ENST00000550375F8W123
ENSG00000185024ENST00000550692F8VXJ4
ENSG00000185024ENST00000551787Q3SYD7
ENSG00000185024ENST00000552127F8VWT8
ENSG00000185024ENST00000619151A3KN61

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription InitiationREACTOMER-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 PromoterREACTOMER-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 PromoterREACTOMER-HSA-76066

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
173694042007TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements.114
121981732002Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover.88
174990432007Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.64
155383812004The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B.62
255615192015BRF1 mutations alter RNA polymerase III-dependent transcription and cause neurodevelopmental anomalies.35
183260312008The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2.33
119975112002CK2 forms a stable complex with TFIIIB and activates RNA polymerase III transcription in human cells.32
179683252008Cellular senescence bypass screen identifies new putative tumor suppressor genes.24
201542702010Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation.21
211065302011Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression.20

Citation

Dessen P

BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50104/brf1