MIR15A (microRNA 15a)

2008-07-01  

Identity

HGNC
LOCATION
13q14.2
LOCUSID
ALIAS
MIRN15A,hsa-mir-15a,miRNA15A,mir-15a

Other Information

Locus ID:

NCBI: 406948
MIM: 609703
HGNC: 31543
Ensembl: ENSG00000283785
miRBase:

Variants:

dbSNP: 406948
ClinVar: 406948
TCGA: ENSG00000283785
COSMIC: MIR15A

RNA/Proteins

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

References

Pubmed IDYearTitleCitations
161662622005miR-15 and miR-16 induce apoptosis by targeting BCL2.1144
184498912008miR-15b and miR-16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells.249
199038412009MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer.92
212058912011MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13.78
214543772011MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E.74
208762852010Oncogenic HER2{Delta}16 suppresses miR-15a/16 and deregulates BCL-2 to promote endocrine resistance of breast tumors.71
188183962009The c-myb proto-oncogene and microRNA-15a comprise an active autoregulatory feedback loop in human hematopoietic cells.66
220023112012Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas.60
253054472015MiR-132, miR-15a and miR-16 synergistically inhibit pituitary tumor cell proliferation, invasion and migration by targeting Sox5.48
229228272012miR-15a and miR-16-1 downregulate CCND1 and induce apoptosis and cell cycle arrest in osteosarcoma.47

Citation

Dessen P

MIR15A (microRNA 15a)

Atlas Genet Cytogenet Oncol Haematol. 2008-07-01

Online version: http://atlasgeneticsoncology.org/gene/50271/mir15a-(microrna-15a)