ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2)

2008-08-01  

Identity

HGNC
LOCATION
10p14
LOCUSID
ALIAS
H2P,SHAP

Other Information

Locus ID:

NCBI: 3698
MIM: 146640
HGNC: 6167
Ensembl: ENSG00000151655

Variants:

dbSNP: 3698
ClinVar: 3698
TCGA: ENSG00000151655
COSMIC: ITIH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151655ENST00000358415P19823
ENSG00000151655ENST00000379587Q5T985
ENSG00000151655ENST00000429820Q5T987

Expression (GTEx)

0
50
100
150
200
250
300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
158405812005Characterization of complexes formed between TSG-6 and inter-alpha-inhibitor that act as intermediates in the covalent transfer of heavy chains onto hyaluronan.62
167022212006SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum.59
184253832008Role of serum-derived hyaluronan-associated protein-hyaluronan complex in ovarian cancer.6
219397892011Human inter-α-inhibitor is a substrate for factor XIIIa and tissue transglutaminase.5
183828972008Hyaluronan (HA) and serum-derived hyaluronan-associated protein (SHAP)-HA complex as predictive markers of cervical ripening in premature labor.2
267284542016The Compact and Biologically Relevant Structure of Inter-α-inhibitor Is Maintained by the Chondroitin Sulfate Chain and Divalent Cations.2
314847222019Matrix-degrading protease ADAMTS-5 cleaves inter-α-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients.1
202977162010[Covalent complex of hyaluronan and serum-derived protein, SHAP is a functional molecule involved in inflammation: finding, structure, formation mechanism, and function of the complex].0

Citation

Dessen P

ITIH2 (inter-alpha-trypsin inhibitor heavy chain 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50300/itih2