RHBDF1 (rhomboid 5 homolog 1)

2008-09-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
C16orf8,Dist1,EGFR-RS,gene-89,gene-90,hDist1
FUSION GENES

Other Information

Locus ID:

NCBI: 64285
MIM: 614403
HGNC: 20561
Ensembl: ENSG00000007384

Variants:

dbSNP: 64285
ClinVar: 64285
TCGA: ENSG00000007384
COSMIC: RHBDF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007384ENST00000262316Q96CC6
ENSG00000007384ENST00000417043F8WCF7
ENSG00000007384ENST00000419764B8ZZ07
ENSG00000007384ENST00000428730F8WBS4
ENSG00000007384ENST00000448893H0Y6L9
ENSG00000007384ENST00000450643A0A1B0GXG1

Expression (GTEx)

0
50
100
150
200
250

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
185248452008Human rhomboid family-1 gene silencing causes apoptosis or autophagy to epithelial cancer cells and inhibits xenograft tumor growth.31
188325972009Human rhomboid family-1 gene RHBDF1 participates in GPCR-mediated transactivation of EGFR growth signals in head and neck squamous cancer cells.29
159659772005Characterization of a human rhomboid homolog, p100hRho/RHBDF1, which interacts with TGF-alpha family ligands.22
209701192011Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.18
265350072015Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.18
246483442014Human rhomboid family-1 suppresses oxygen-independent degradation of hypoxia-inducible factor-1α in breast cancer.13
261094052015iRhom1 regulates proteasome activity via PAC1/2 under ER stress.8
296547412018RHBDF1 regulates APC-mediated stimulation of the epithelial-to-mesenchymal transition and proliferation of colorectal cancer cells in part via the Wnt/β-catenin signalling pathway.5
302791412018Human rhomboid family-1 modulates clathrin coated vesicle-dependent pro-transforming growth factor α membrane trafficking to promote breast cancer progression.2

Citation

Dessen P

RHBDF1 (rhomboid 5 homolog 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50317/rhbdf1-(rhomboid-5-homolog-1)