HRH1 (histamine receptor H1)

2008-09-01  

Identity

HGNC
HRH1
LOCATION
3p25.3
LOCUSID
3269
ALIAS
H1-R,H1R,HH1R,hisH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3269
MIM: 600167
HGNC: 5182
Ensembl: ENSG00000196639

Variants:

dbSNP: 3269
ClinVar: 3269
TCGA: ENSG00000196639
COSMIC: HRH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196639ENST00000397056P35367
ENSG00000196639ENST00000413416C9J2E6
ENSG00000196639ENST00000431010P35367
ENSG00000196639ENST00000438284P35367

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Histamine receptorsREACTOMER-HSA-390650
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406954Weight gainDiseaseMultilinkAnnotationassociated24279860
PA164776964desloratadineChemicalClinicalAnnotationassociatedPD31406237
PA166129521sedationDiseaseClinicalAnnotationassociatedPD31406237
PA445999UrticariaDiseaseClinicalAnnotationassociatedPD31406237

References

Pubmed IDYearTitleCitations
379778232024Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H(1) Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine.0
385423692024Histamine H(1) Receptor-Mediated JNK Phosphorylation Is Regulated by G(q) Protein-Dependent but Arrestin-Independent Pathways.0
379778232024Pharmacological Characterization of the Zebrafish (Danio Rerio) Histamine H(1) Receptor Reveals the Involvement of the Second Extracellular Loop in the Binding of Histamine.0
385423692024Histamine H(1) Receptor-Mediated JNK Phosphorylation Is Regulated by G(q) Protein-Dependent but Arrestin-Independent Pathways.0
367323362023Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration.4
372018782023Differential regulation of histamine H(1) receptor-mediated ERK phosphorylation by G(q) proteins and arrestins.1
373007032023Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines.0
367323362023Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration.4
372018782023Differential regulation of histamine H(1) receptor-mediated ERK phosphorylation by G(q) proteins and arrestins.1
373007032023Histamine H(1)- and H(4)-receptor expression in human colon-derived cell lines.0
345957422022Molecular Signaling and Transcriptional Regulation of Histamine H(1) Receptor Gene.4
350314802022Epigallocatechin gallate stimulated histamine production and downregulated histamine H1 receptor in oral cancer cell lines expressing histidine decarboxylase.1
345957422022Molecular Signaling and Transcriptional Regulation of Histamine H(1) Receptor Gene.4
350314802022Epigallocatechin gallate stimulated histamine production and downregulated histamine H1 receptor in oral cancer cell lines expressing histidine decarboxylase.1
339181802021Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410(6.30×30)K Variant in the Histamine H(1) Receptor.4

Citation

Dessen P

HRH1 (histamine receptor H1)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50324/favicon/favicon/favicon-32x32.png