FAAH (fatty acid amide hydrolase)

2008-09-01 Affiliation

Identity

HGNC

FAAH

LOCATION

1p33

LOCUSID

2166

ALIAS

FAAH-1,PSAB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2166
MIM: 602935
HGNC: 3553
Ensembl: ENSG00000117480

Variants:

dbSNP: 2166
ClinVar: 2166
TCGA: ENSG00000117480
COSMIC: FAAH

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000117480	ENST00000243167	O00519
ENSG00000117480	ENST00000484697	A0A087WYA0

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Retrograde endocannabinoid signaling	KEGG	hsa04723
Retrograde endocannabinoid signaling	KEGG	ko04723
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA10026	aripiprazole	Chemical	ClinicalAnnotation	associated	PD	20631561
PA131890620	cannabinoids	Chemical	ClinicalAnnotation	associated	PD	17290447
PA444702	Kyphosis	Disease	VariantAnnotation	associated	PD
PA445522	Respiratory Insufficiency	Disease	VariantAnnotation	ambiguous	PD
PA445619	Scoliosis	Disease	VariantAnnotation	associated	PD
PA446876	Substance-Related Disorders	Disease	ClinicalAnnotation	associated	PD	17290447, 23556448, 31789429
PA446970	Postoperative Nausea and Vomiting	Disease	VariantAnnotation	not associated	PD
PA447215	Psychotic Disorders	Disease	ClinicalAnnotation	associated	PD	20631561
PA449061	clozapine	Chemical	ClinicalAnnotation	associated	PD	20631561
PA449841	haloperidol	Chemical	ClinicalAnnotation	associated	PD	20631561
PA449957	ibuprofen	Chemical	Pathway	associated		25502615
PA450403	methamphetamine	Chemical	ClinicalAnnotation	associated	PD	23556448, 31789429
PA450550	morphine	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous	PD
PA450688	olanzapine	Chemical	ClinicalAnnotation	associated	PD	20631561
PA451201	quetiapine	Chemical	ClinicalAnnotation	associated	PD	20631561
PA451257	risperidone	Chemical	ClinicalAnnotation	associated	PD	20631561
PA452618	opioids	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
38114812	2024	Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.	0
38114812	2024	Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.	0
34171108	2023	Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population.	6
35900294	2023	Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective.	3
36300805	2023	Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases.	2
36372184	2023	Endocannabinoid hydrolases differentially distribute in platelets and red blood cells and are differentially released by thrombin.	1
36868890	2023	Association Between Fatty Acid Amide Hydrolase and Alcohol Response Phenotypes: A Positron Emission Tomography Imaging Study With [(11)C]CURB in Heavy-Drinking Youth.	3
37018974	2023	The study of rs324420 (C385A) polymorphism of the FAAH gene of the endocannabinoid system in patients with epilepsy and ADHD.	1
37253733	2023	Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer.	2
37372343	2023	Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players.	2
37433211	2023	FAAH Pro129Thr Variant Is Associated with Increased Cholesterol Levels in Normal-Weight Metabolically Unhealthy Subjects.	0
37761966	2023	Functional Variation in the FAAH Gene Is Directly Associated with Subjective Well-Being and Indirectly Associated with Problematic Alcohol Use.	2
34171108	2023	Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population.	6
35900294	2023	Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective.	3
36300805	2023	Fatty acid amide hydrolase C385A polymorphism affects susceptibility to various diseases.	2

Citation

Dessen P

FAAH (fatty acid amide hydrolase)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50330/gene-fusions-explorer/css/template-card.css