LBH (LBH regulator of WNT signaling pathway)

2008-09-01  

Identity

HGNC
LOCATION
2p23.1
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 81606
MIM: 611763
HGNC: 29532
Ensembl: ENSG00000213626

Variants:

dbSNP: 81606
ClinVar: 81606
TCGA: ENSG00000213626
COSMIC: LBH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213626ENST00000395323Q53QV2
ENSG00000213626ENST00000401506B5MCP4
ENSG00000213626ENST00000404397B5MC28
ENSG00000213626ENST00000406087B5MCM2
ENSG00000213626ENST00000407930B5MBX5
ENSG00000213626ENST00000412933F8WC18

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
206060072010The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers.39
159585142005Congenital heart disease reminiscent of partial trisomy 2p syndrome in mice transgenic for the transcription factor Lbh.23
257074782015The Rheumatoid Arthritis Risk Gene LBH Regulates Growth in Fibroblast-like Synoviocytes.21
205466122010The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.19
173902362008A human homolog of mouse Lbh gene, hLBH, expresses in heart and activates SRE and AP-1 mediated MAPK signaling pathway.14
255578372015Limb-bud and Heart (LBH) functions as a tumor suppressor of nasopharyngeal carcinoma by inducing G1/S cell cycle arrest.13
271598402016LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis.13
297880152018Limb-Bud and Heart Attenuates Growth and Invasion of Human Lung Adenocarcinoma Cells and Predicts Survival Outcome.7
261345862016Downregulated expression of LBH mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.3

Citation

Dessen P

LBH (LBH regulator of WNT signaling pathway)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50369/lbh