DAND5 (DAN domain BMP antagonist family member 5)

DAND5 (DAN domain BMP antagonist family member 5)

2008-10-01 Affiliation

Identity

HGNC

LOCATION

19p13.13

LOCUSID

ALIAS

CER2,CERL2,CKTSF1B3,COCO,CRL2,DANTE,GREM3,SP1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 199699
MIM: 609068
HGNC: 26780
Ensembl: ENSG00000179284

Variants:

dbSNP: 199699
ClinVar: 199699
TCGA: ENSG00000179284
COSMIC: DAND5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000179284	ENST00000317060	Q8N907
ENSG00000179284	ENST00000585548	K7EQF6

Expression (GTEx)

0

1

2

3

4

5

6

7

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Developmental Biology	REACTOME	R-HSA-1266738
Signaling by NODAL	REACTOME	R-HSA-1181150
Regulation of signaling by NODAL	REACTOME	R-HSA-1433617

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36316122	2022	A novel biallelic loss-of-function variant in DAND5 causes heterotaxy syndrome.	0
36316122	2022	A novel biallelic loss-of-function variant in DAND5 causes heterotaxy syndrome.	0
31869685	2020	Generation of a gene-corrected human induced pluripotent stem cell line derived from a patient with laterality defects and congenital heart anomalies with a c.455G > A alteration in DAND5.	2
31869685	2020	Generation of a gene-corrected human induced pluripotent stem cell line derived from a patient with laterality defects and congenital heart anomalies with a c.455G > A alteration in DAND5.	2
30685069	2019	Reduced levels of Coco in sera of multiple sclerosis patients: A potential role in neuro-regeneration failure.	3
30685069	2019	Reduced levels of Coco in sera of multiple sclerosis patients: A potential role in neuro-regeneration failure.	3
28738792	2017	Functional study of DAND5 variant in patients with Congenital Heart Disease and laterality defects.	8
28738792	2017	Functional study of DAND5 variant in patients with Congenital Heart Disease and laterality defects.	8
26908452	2016	The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer.	6
26908452	2016	The BMP inhibitor DAND5 in serum predicts poor survival in breast cancer.	6
22901808	2012	The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites.	209
22901808	2012	The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites.	209

Citation

Dessen P

DAND5 (DAN domain BMP antagonist family member 5)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50397/css/lib/js/lib/popper.js