ARNT2 (aryl hydrocarbon receptor nuclear translocator 2)

2008-10-01  

Identity

HGNC
LOCATION
15q25.1
LOCUSID
ALIAS
WEDAS,bHLHe1
FUSION GENES

Other Information

Locus ID:

NCBI: 9915
MIM: 606036
HGNC: 16876
Ensembl: ENSG00000172379

Variants:

dbSNP: 9915
ClinVar: 9915
TCGA: ENSG00000172379
COSMIC: ARNT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172379ENST00000303329Q9HBZ2
ENSG00000172379ENST00000303329X5DQN9
ENSG00000172379ENST00000525103H0YKW1
ENSG00000172379ENST00000527771Q9HBZ2
ENSG00000172379ENST00000533983Q9HBZ2
ENSG00000172379ENST00000622346A0A087WVE9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Renal cell carcinomaKEGGko05211
Pathways in cancerKEGGhsa05200
Renal cell carcinomaKEGGhsa05211
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945
Cytochrome P450 - arranged by substrate typeREACTOMER-HSA-211897
Endogenous sterolsREACTOMER-HSA-211976
XenobioticsREACTOMER-HSA-211981
Aryl hydrocarbon receptor signallingREACTOMER-HSA-8937144

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
363432532022Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.0
363432532022Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.0
319647432020Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis.5
319647432020Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis.5
299485062019Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer.5
299485062019Overexpression of ARNT2 is associated with decreased cell proliferation and better prognosis in gastric cancer.5
291494192018Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness.13
291944992018Emotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2.5
291494192018Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness.13
291944992018Emotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2.5
256130632015ARNT2 is downregulated and serves as a potential tumor suppressor gene in non-small cell lung cancer.9
256130632015ARNT2 is downregulated and serves as a potential tumor suppressor gene in non-small cell lung cancer.9
244656932014Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.13
246356602014Associations between oxytocin-related genes and autistic-like traits.20
248143682014Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.5

Citation

Dessen P

ARNT2 (aryl hydrocarbon receptor nuclear translocator 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50423/css/js/favicon/favicon-16x16.png