GUK1 (guanylate kinase 1)

2008-10-01  

Identity

HGNC
GUK1
LOCATION
1q42.13
LOCUSID
2987
ALIAS
GMK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2987
MIM: 139270
HGNC: 4693
Ensembl: ENSG00000143774

Variants:

dbSNP: 2987
ClinVar: 2987
TCGA: ENSG00000143774
COSMIC: GUK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143774ENST00000312726Q16774
ENSG00000143774ENST00000312726Q6IBG8
ENSG00000143774ENST00000366716Q16774
ENSG00000143774ENST00000366716Q6IBG8
ENSG00000143774ENST00000366718Q16774
ENSG00000143774ENST00000366718Q6IBG8
ENSG00000143774ENST00000366721B1ANH5
ENSG00000143774ENST00000366722B1ANH6
ENSG00000143774ENST00000366723B1ANG9
ENSG00000143774ENST00000366726Q16774
ENSG00000143774ENST00000366726Q6IBG8
ENSG00000143774ENST00000366728Q16774
ENSG00000143774ENST00000366730Q16774
ENSG00000143774ENST00000366730Q6IBG8
ENSG00000143774ENST00000391865Q16774
ENSG00000143774ENST00000412265B1ANH2
ENSG00000143774ENST00000435153B1ANH3
ENSG00000143774ENST00000453943B1ANH0

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Metabolic pathwaysKEGGhsa01100
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGM00050
Guanine ribonucleotide biosynthesis IMP => GDP,GTPKEGGhsa_M00050
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943
Abacavir transport and metabolismREACTOMER-HSA-2161522
Abacavir metabolismREACTOMER-HSA-2161541

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
168325842006Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) and guanylate kinase 1 (GUK1) are differentially expressed in GH-secreting adenomas.2
316820092020Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.0

Citation

Dessen P

GUK1 (guanylate kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/50432/guk1-(guanylate-kinase-1)