TNIP1 (TNFAIP3 interacting protein 1)

2008-12-01  

Identity

HGNC
TNIP1
LOCATION
5q33.1
LOCUSID
10318
ALIAS
ABIN-1,NAF1,VAN,nip40-1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10318
MIM: 607714
HGNC: 16903
Ensembl: ENSG00000145901

Variants:

dbSNP: 10318
ClinVar: 10318
TCGA: ENSG00000145901
COSMIC: TNIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145901ENST00000315050Q15025
ENSG00000145901ENST00000389378A0A0A0MRZ4
ENSG00000145901ENST00000517504H0YC17
ENSG00000145901ENST00000518977Q15025
ENSG00000145901ENST00000519339E7EMV7
ENSG00000145901ENST00000520695E7EW68
ENSG00000145901ENST00000520931Q15025
ENSG00000145901ENST00000521001E7EWG2
ENSG00000145901ENST00000521591Q15025
ENSG00000145901ENST00000522100E7EW15
ENSG00000145901ENST00000522226Q15025
ENSG00000145901ENST00000523200Q15025
ENSG00000145901ENST00000523338Q15025
ENSG00000145901ENST00000524280Q15025
ENSG00000145901ENST00000610535Q15025
ENSG00000145901ENST00000610874Q15025

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
388099172024Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3.1
388099172024Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer's disease highlights a potential role for GPX3.1
365742652023TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.6
368474142023The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR.2
368983702023TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.9
377517952023TNFAIP3-interacting protein 1 polymorphisms and their association with symptomatic human respiratory syncytial virus infection and bronchiolitis in infants younger than one year from South Africa: A case-control study.0
365742652023TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.6
368474142023The inflammation repressor TNIP1/ABIN-1 is degraded by autophagy following TBK1 phosphorylation of its LIR.2
368983702023TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1.9
377517952023TNFAIP3-interacting protein 1 polymorphisms and their association with symptomatic human respiratory syncytial virus infection and bronchiolitis in infants younger than one year from South Africa: A case-control study.0
350425402022Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1.10
350996072022A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells.11
354753712022Assessment of the association between TNIP1 polymorphism with clinical features and risk of systemic lupus erythematosus.0
360344122022ABIN1 Inhibits Inflammation through Necroptosis-Dependent Pathway in Ulcerative Colitis.2
360549342022Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms.2

Citation

Dessen P

TNIP1 (TNFAIP3 interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50501/gene-fusions/meetings/js/lib/bootstrap.min.js