TNIP1 (TNFAIP3 interacting protein 1)

2008-12-01  

Identity

HGNC
LOCATION
5q33.1
LOCUSID
ALIAS
ABIN-1,NAF1,VAN,nip40-1
FUSION GENES

Other Information

Locus ID:

NCBI: 10318
MIM: 607714
HGNC: 16903
Ensembl: ENSG00000145901

Variants:

dbSNP: 10318
ClinVar: 10318
TCGA: ENSG00000145901
COSMIC: TNIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145901ENST00000315050Q15025
ENSG00000145901ENST00000389378A0A0A0MRZ4
ENSG00000145901ENST00000517504H0YC17
ENSG00000145901ENST00000518977Q15025
ENSG00000145901ENST00000519339E7EMV7
ENSG00000145901ENST00000520695E7EW68
ENSG00000145901ENST00000520931Q15025
ENSG00000145901ENST00000521001E7EWG2
ENSG00000145901ENST00000521591Q15025
ENSG00000145901ENST00000522100E7EW15
ENSG00000145901ENST00000522226Q15025
ENSG00000145901ENST00000523200Q15025
ENSG00000145901ENST00000523338Q15025
ENSG00000145901ENST00000524280Q15025
ENSG00000145901ENST00000610535Q15025
ENSG00000145901ENST00000610874Q15025

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191692542009Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.410
198381932009Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.332
198381952009A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.316
198381952009A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.316
166847682006ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB.95
182127362008Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins.93
217506792011Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis.82
216065072011Polyubiquitin binding to ABIN1 is required to prevent autoimmunity.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
194644282009ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling.61

Citation

Dessen P

TNIP1 (TNFAIP3 interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50501/tnip1-(tnfaip3-interacting-protein-1)