AHCY (adenosylhomocysteinase)

2008-12-01 Affiliation

Identity

HGNC

AHCY

LOCATION

20q11.22

LOCUSID

191

ALIAS

SAHH,adoHcyase

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 191
MIM: 180960
HGNC: 343
Ensembl: ENSG00000101444

Variants:

dbSNP: 191
ClinVar: 191
TCGA: ENSG00000101444
COSMIC: AHCY

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000101444	ENST00000217426	P23526
ENSG00000101444	ENST00000217426	A0A384MTQ3
ENSG00000101444	ENST00000538132	P23526

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cysteine and methionine metabolism	KEGG	ko00270
Cysteine and methionine metabolism	KEGG	hsa00270
Metabolic pathways	KEGG	hsa01100
Methionine degradation	KEGG	hsa_M00035
Methionine degradation	KEGG	M00035
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Sulfur amino acid metabolism	REACTOME	R-HSA-1614635
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Methylation	REACTOME	R-HSA-156581
Selenoamino acid metabolism	REACTOME	R-HSA-2408522
Metabolism of ingested SeMet, Sec, MeSec into H2Se	REACTOME	R-HSA-2408508

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
26687445	2015	H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase.	59
19161160	2009	An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).	30
12590576	2003	Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: transition-state stabilization and the avoidance of abortive reactions.	25
17688412	2007	Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs.	25
19683694	2009	Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida.	23
18978678	2008	Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.	21
18635682	2008	Genetic analysis of 56 polymorphisms in 17 genes involved in methionine metabolism in patients with abdominal aortic aneurysm.	20
18713839	2008	S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis.	20
19048631	2009	Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.	20

Citation

Dessen P

AHCY (adenosylhomocysteinase)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50513/ahcy