TRPM2 (transient receptor potential cation channel subfamily M member 2)

2008-12-01 Affiliation

Identity

HGNC

TRPM2

LOCATION

21q22.3

LOCUSID

7226

ALIAS

EREG1,KNP3,LTRPC2,LTrpC-2,NUDT9H,NUDT9L1,TRPC7

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 7226
MIM: 603749
HGNC: 12339
Ensembl: ENSG00000142185

Variants:

dbSNP: 7226
ClinVar: 7226
TCGA: ENSG00000142185
COSMIC: TRPM2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000142185	ENST00000300481	O94759
ENSG00000142185	ENST00000300482	O94759
ENSG00000142185	ENST00000397928	O94759
ENSG00000142185	ENST00000397932	E9PGK7
ENSG00000142185	ENST00000431901	C9JZQ8
ENSG00000142185	ENST00000621064	A0A087WT16

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Ion channel transport	REACTOME	R-HSA-983712
Stimuli-sensing channels	REACTOME	R-HSA-2672351
TRP channels	REACTOME	R-HSA-3295583
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
11804595	2002	LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.	211
15561722	2005	Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels.	124
16601673	2006	TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion.	122
15808509	2005	Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels.	112
12529379	2003	Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation.	95
19454650	2009	TRPM2 functions as a lysosomal Ca2+-release channel in beta cells.	94
18048770	2008	Role of TRPM2 channel in mediating H2O2-induced Ca2+ entry and endothelial hyperpermeability.	83
16585058	2006	Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes.	72
12594222	2003	A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death.	71
16565078	2006	Metabolite of SIR2 reaction modulates TRPM2 ion channel.	60

Citation

Dessen P

TRPM2 (transient receptor potential cation channel subfamily M member 2)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50540/trpm2